Objective:This study aims to determine the effect that occurs when heat cured acrylic resin is added hydroxyapatite which is synthesized from skipjack fish bones.

Material and Methods: This study using 27 samples of heat cured acrylic resin for each mechanical strength divided into 3 groups, namely groups with the addition of 0%, 2%, and 5% hydroxyapatite from the weight of the polymer.

Results: The analysis showed a significant decrease in transverse strength with 5% addition of hydroxyapatite group (One-way Anova test, p = 0.001), a significant decrease in impact strength occurred in both groups of 2% and 5% addition of hydroxyapatite (One-way Anova test, p = 0.000), and also the addition of 2% & 5% hydroxyapatite caused a significant decrease in tensile strength (One-way Anova test, p = 0.018).

Conclusion: Hydroxyapatite synthesized from skipjack fish bone affects the mechanical strength of acrylic resins, namely transverse, impact and tensile.

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