Calcium, phosphor and alkaline phospatase value in bone graft calsium sulfat hemihydrate bioceramic application on animal bone defect (In Vivo Study)
Abstract
Objective: This study aims to determine differences in the value of calcium, phosphor, and alkaline phosphatase in the blood of bone graft material which is applied to bone defectsMethods: 12 male rabbits were divided into 4 groups, then defects were made in the femur bone with a diameter of 5mm. then each group was drawn with a vulnerable blood pre-operative time, 1 week, 3 weeks, and 6 weeks after surgery.Result: Average levels of calcium, alkaline phosphate and phosphorus in all treatment groups were higher than those in the control group.Conclusion: There were differences in calcium levels in test animals using bone graft α-calcium sulphate hemihydrates bioceramic on days 7th, 21st, and 42nd post surgery.
Section
References
- Nemcovsky CE. Clinical evaluation of particulate allogeneic with and without autogenous bone grafts and resorbable collagen membranes for bone augmentation of atrophic alveolar ridges. 2010:1242-1250. doi:10.1111/j.1600-0501.2010.01936.x.
- Ezirganli S, Kazancioglu HO, Mihmanli A, Sharifov R, Aydin MS. Effects of different biomaterials on augmented bone volume resorptions. 2014:1482-1488. doi:10.1111/clr.12495.
- Markel DC, Guthrie ST, Wu B. Characterization of the inflammatory response to four commercial bone graft substitutes using a murine biocompatibility model. 2012:13-18.
- C YK, Nalini KB, Menon J, Patro DK, Banerji BH. Calcium Sulfate as Bone Graft Substitute in the Treatment of Osseous Bone Defects , A Prospective Study. 2013;7(12):2926-2928. doi:10.7860/JCDR/2013/6404.3791.
- Hsu HJ, Waris RA, Ruslin M, Lin YH, Chen CS, Ou KL. An innovative α-calcium sulfate hemihydrate bioceramic as a potential bone graft substitute. J Am Ceram Soc. 2018;101(1):419-427. doi:10.1111/jace.15181.
- Adytha A. SEL PUNCA PULPA GIGI ( DITINJAU DARI AKTIVITAS ENZIM ALKALINE PHOSPHATASE ) SEL PUNCA DENTAL PULPA ( DITINJAU DARI AKTIVITAS ENZIM ALKALINE PHOSPHATASE ). 2012
- Saraswathy G, Sastry T.P, Pal S., Sreenu Makeena, Kumar R.V.S. A new bio-inorganic composite as bone grafting material: in vivo study. Trends Biomater. Artif.Organs 2004; Vol.17(2): 37-42.
- Mishra Ruchi, Raina D.B., and Kumar Ashok. Study of in vitro and in vivo bone formation in composite cryogels and the influence of electrical stimulation. Int J Biol Sci 2015; 11(11): 1325-1336.
- Xie Minli, Olderoy Magnus, Zhang Zhibing, Andreassen Petter Jens, Strand Berit L, and Siroski Pawel. Biocomposites prepared by alkaline hosphatase mediated mineralization of alginate microbeads. RSC Adv 2012; 2: 1457-1465.
- Bonjour JP. Calcium and phosphate: a duet of ions playing for bone health. J Am Coll Nutr 2011; 30(5): 438-448.
- Mao Keya, Zhou Feihu, Cui Fuzai, Li Jiangtao, Hou Xijun, Li Peng, Du Mingkui, et al. Preparation and properties of α-calcium sulphate hemihydrates and β-tricalcium phosphate bone substitute. Bio-Med Mat Eng 2013; 23: 197-210.
- Chen C, Zhu C, Hu X, Yu Q, Zheng Q, Tao S, and Fan L. α-hemihydrate calcium sulphate/pctacalcium phosphate combine with sodium hyaluronate promotes bone marrow-derived mesenchymal stem cell osteogenesis in vitro and in vivo. J Drug Design Dev Therapy 2018; 12: 3269-3287.
- Xiang Haibo,Wang Yu, Chang Hong, Yang Shenyu, Tu Mei, Zhang Xianrong, and Yu Bin. Cerium-containing α-calcium sulphate hemihydrate bone substitute promotes osteogenesis. J Biomat App 2019; 34(2): 250-260.
- Liu Zhi, Yu Zewei, Chang Hong, Wang Yu, Xiang Haibo, Zhang Xianrong, Yu Bin. Strontium-containing α-calcium sulphate hemihydrate promotes bone repair via the TGF-β/smad signalling pathway. Mol Med Rep 2019; 20: 3555-3564.
How to Cite
Thalib, B., Utama, M. D., Machmud, E., Asmawati, A., Winarto, S., & Intang, N. (2019). Calcium, phosphor and alkaline phospatase value in bone graft calsium sulfat hemihydrate bioceramic application on animal bone defect (In Vivo Study). Journal of Dentomaxillofacial Science, 4(3), 145–149. https://doi.org/10.15562/jdmfs.v4i3.1021