Original Article

Effect of cats tail leaves extract (acalypha hispida burm. f.) on wound healing (traumatic ulcer) of wistar male rat oral mucosa (rattus norvegicus)

Sumintarti Sumintarti , Jessica Juliana

Sumintarti Sumintarti
Departement of Oral Medicine, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia. Email: sumintarti01@gmail.com

Jessica Juliana
Departement of Oral Medicine, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia
Online First: April 01, 2020 | Cite this Article
Sumintarti, S., Juliana, J. 2020. Effect of cats tail leaves extract (acalypha hispida burm. f.) on wound healing (traumatic ulcer) of wistar male rat oral mucosa (rattus norvegicus). Journal of Dentomaxillofacial Science 5(1): 56-61. DOI:10.15562/jdmfs.v5i1.1057


Objective: This study aims to determine the effect of cats tail leaves extract (Acalypha hispida Burm. F.) on wound healing ofWistar male rat mucosa (Rattus norvegicus) as the result of this experimental which obtained later can be used as a reference in dentistry to develop cats tail leaves as an alternative medicine in traumatic ulcer treatment..

Material and Methods: This is an experimental research with post-test only control group design.The experimental subject were 24 Wistar male rat divided into four treatment groups, including a 50% A. hispida leaves group, a 75% A. hispida leaves group, a 100% A. hispida leaves group, and povidone iodine control group. All rat in every group were given the treatment and the decrease of wound diameter were measured for 8 days then the data were processed using SPSS program. 

Results:The average of traumatic wound diameter on 8th day is 0.33±0.41 mm for 50% A. hispida leaves group, 0.50±0.45 mm for 75% A. hispida leaves group, 0.25±0.42 mm for 100% A. hispida leaves group, and 1.17±0.61 mm for control group. Based on Friedman test and Wilcoxon test, the result shows significant difference on wound diameter change in every treatment group. 

Conclusion: Cats tail leaves extract (acalypha hispida burm. F.) with concentration of 50%, 75%, and 100% have the effect of wound healing on traumatic injury of white rat oral mucosa (rattus novergicus) but there is no significant difference in effectivenessbetween every concentration. 

References

Scully C. Oral & maxillofacial medicine: the basis of diagnosis and treatment. 3rd ed. Churchill Livingstone: Elsevier; 2013. p. 154.

Cavalcante GM, Paula RJSd, Souza LPd, et al. Experimental model of traumatic ulcer in the cheek mucosa of rats. Acta Cir Bras 2011;26: 227-234

Moningka KC, Kojong NS, Sudewi S. Antibacterial activity test of cat tail (Acalypha hispida Burm. F.) leaf extract against staphylococcus aureus and Escherichia coli bacteria in vitro. Pharmacon J Ilmiah Farmasi 2015;4: 193-202. (In Indonesia)

Febriyanti M, Sanjaya BW, Supriyatma, et al. Antioxidant activity of ethanol extract and fractions of cat tail leaves (Acalypha hispida Burm. F.) by the method of inhibiting the reduction of water soluble tetrazolium salt-1 (WST-1). Fitofarmaka 2013;3: . (In Indonesia)

Osarumwense PO, Okunrobo LO. Phytochemical screening and the antimicrobial properties of Acalypha hispida Burm. F. (Euphorbiaceae). AJOPRED 2013;5: 36-39.

Siraj MA. Anti-inflammatory and antioxidant activity of acalypha hispida leaf and analysis of its major bioactive polyphenols by HPLC. Adv Pharm Bull 2016;6: 275-283.

Wijaya BA, Citraningtyas G, Wehantouw F. Potential of ethanol extract of taro leaf stalk (colocasia esculenta [L]) as an alternative medicine for wound on rabbit skin (Oryctolagus cuniculus). Pharmacon J Ilmiah Farmasi 2014;3: 211-219. (In Indonesia)

Ruswanti EO, Cholil, Sukmana BI. The effectiveness of etaya extract of papaya leaves (carica papaya) 100% of wound healing time. Dentino J Kedok Gigi 2014;2: 162-166. (In Indonesia)

Sumoza NS, Efrizal, Rahayu R. Effect of gambier (Uncaria gambir R.) on the healing of burns in male white mice (Mus musculus L.). J Bio UA 2014;3: 283-288. (In Indonesia)

Fuadi MI, Elfiah U, Misnawi. The number of fibroblasts in second-degree burns in rats by giving ethanol extract gel of cocoa beans and silver sulfadiazine. eJPK 2015;3: 244-248. (In Indonesia)

Rupina W, Trianto HF, Fitrianingrum I. Effect of 70% ethanol extract ointment on caramunting leaves on re- epithelialization of wistar rat skin incision wounds. eJKI 2016;4: 26-30. (In Indonesia)

Kusumawardhani AD, Kalsum U, Rini IS. Effect of betel leaf extract ointment (piper betle Linn.) on the number of fibroblasts of degree IIA burns in white rats (rattus novergicus) wistar strain. Majalah Kesehatan FKUB 2015;2: 16-28. (In Indonesia)

Onocha PA, Oloyede GK, Afolabi QO. Phytochemical investigation, cytotoxicity and free radical scavenging activities of non-polar fractions of acalypha hispida (leaves and twigs). EXCLI J 2011;10: 1-8.

Putri NT, Sarianoferni, Wahjuningsih E. The effect of low LET (Linear Energy Transfer) ionizing radiation to catalase activity of wistar’s submandibular gland. J Dentomaxillofac Sci 2016;1: 145-149.


No Supplementary Material available for this article.
Article Views      : 178
PDF Downloads : 108