Skip to main content Skip to main navigation menu Skip to site footer

Levels of salivary malondialdehyde In traumatic ulcer patients


AbstractObjective: Traumatic ulcers are oral mucosal lesions that are often encountered with the healing process of wounds involving inflammatory mediators and phagocytosis process. Phagocytosis can produce free radicals that the potential to cause cells damage and lipid peroxidation. Lipid peroxidation produce malondialdehyde (MDA) as end products. Saliva is a biological specimen can detect MDA level in oxidative stress condition. This study aims to analyse differences in levels of salivary MDA in traumatic ulcer participants compared to healthy individual subjects. Material and Method: The research methods was cross sectional study. MDA levels measured in saliva of 50 subjects, aged 20-25 years. Traumatic ulcer lesion subjects and healthy individual without lesions would be taken unstimulated saliva samples.  Salivary MDA levels determined with TBARs method. Data were analyzed statistically with Mann Whitney's test (p<0,05).Results: Showed that there were differences in salivary MDA levels in traumatic ulcer participants compared to healthy individual subjects (p=0,0001). Conclusion: Free radicals have been implicated in the pathogenesis of oral mucosal lesions, including traumatic ulcer. Increase in MDA levels in the saliva of participants may provide a biomarker for oxidative stress in oral mucosa disease.


  1. References
  2. Riskesdas. National Riskesdas Report 2018. Indonesia; 2018.
  3. Sunarjo L, Hendari R, Rimbyastuti H. The benefits of xanthones on healing oral cavity ulcers are seen from the number of PMN cells and fibroblasts. ODONTO Dental Journal 2015; 2.
  4. Khalili J. Biloklytska HF. Salivary malondialdehyde levels in clinically healthy and periodontal diseased individuals. Oral disease 2008.
  5. Yuslianti ER. Free radicals and antioxidants. 1st Yogyakarta: Deepublish; 2017. p.13-16.
  6. Widayati E Biological oxidation, free radicals, and antioxidants. Magazine scientific Sultan Agung 2012; 50.
  7. Balogh MB, Fehrenbach MJ. Illustrated dental embryology, histology, and anatomy. 3rd ed. Killney: Elsevier 2012; 132.
  8. Rai B, Kharb S, Jain R, Anand SC. Salivary Lipid Peroxidation Product Malonaldehyde in Various Dental Diseases. World Journal of Medical Sciences 2006; 2.
  9. Phaniendra A, Jestadi DB, Periyasamy. Free radicals: Properties, sources, targets, and their implications in various diseases. Indian J Clin Biochem 2015; 30 (1): 11-26. doi: 10.1007 / s12291-014-0446-0.
  10. Tothova Lb, Kamodyova N, Cervenka T, Celec P. Salivary markers of oxidative stress in oral diseases. fronties in celullar and microbiology infection 2015.
  11. Farnaud, S. J., Kosti, O., Getting, S. J., and Renshaw, D. Saliva: physiology and diagnostic potential in health and disease. Scientific World Journal 2010; 10: 434–456. doi: 10.1100 / tsw., 38.
  12. Bandewar, S. V. "Cioms 2016." Indian J Med Ethics 2 2017; pp: 138-40.
  13. Nicolaides, Angelo. "Bioethical considerations, the common good approach and some shortfalls of the Belmont Report." Medical Technology SA 2016; 30: 15-24.
  14. Faculty of Medicine, Universitas Achmad Yani. Medical skills manual (BPKM) Clinical medicine and oral manifestations. Indonesia; Cimahi; 2018.
  15. Khalili, J., and H. F. Biloklytska. "Salivary malondialdehyde levels in clinically healthy and periodontal diseased individuals." Oral diseases 2018; 14: 754-760.
  16. Faculty of Medicine, Jenderal Achamd Yani University. Practicum basic biomedical 1. Indonesia; Cimahi; 2019.
  17. Jat D. Mechanism of action of antioxidants against free radical mediated damage to biomolecules. Madhya Bharti Journal of Science 2016; 60: 06-08.
  18. Sarma AD, Mallick AR, Ghosh AK. Free radicals and their role in different clinical conditions: An overview. International Journal of Pharma Sciences and Research (LIPSR) 2010; 185-192.
  19. Dizdaroglu M. Jaruga P. Mechanisms of freeradical induced damage to DNA. Free radical research 2012; 46.
  20. Setyopranoto I. Role of oxidative stress on acute ischaemic stroke. Indonesian Journal of Medicine and Health 2016; 7.
  21. Sardaro N, Vella FD, Incalza MA, Stasio DD, Lucchese A, Contaldo M, Laudadio C, Petruzzi M. Oxidative stress and oral mucosal diseases: an overview. NCBI. 2019; 33: 289-296.
  22. Fitriyana N, Arina Y, Harmono H, Susilawati I. The effect of porphyromonas gingivalis induction on neutrophil’s superoxide production. Dentofasial 2013; 12; p.152-158.
  23. Primadina. N Basori. Perdanakusuma A. The process of wound healing in terms of aspects of cellular and molecular mechanisms. Qanum medika 2018; 3.
  24. Purnama H. Sriwidodo. Ratnawulan S. Review sistematik proses penyembuhan dan perawatan luka. Farmaka suplemen 2017; 15.
  25. Laskaris G. Color atlas of oral diseases. Thieme medical publishers 1986.
  26. Hoff JWVD. Maltha JC. Jagtman AM. Palatal wound healing : the effects of scarring on growth. In: Cleft lip and palate. Springer, Berlin, Heidelberg 2016; 301-313.

How to Cite

Yuslianti, E. R., Sutjiatmo, A. B., Muzaky, R. F., Zhafarina, M., & Radani, A. H. (2022). Levels of salivary malondialdehyde In traumatic ulcer patients. Journal of Dentomaxillofacial Science, 7(1), 9–13.




Search Panel