Original Article

Acceleration of granulation tissue using myrmecodiapendens extract induction during wound healing tooth extraction process (experimental research on caviacobaya)

Efa Ismardianita , Wenny Rosalina

Efa Ismardianita
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Baiturrahmah, Padang, Indonesia. Email: efa_ismardianita@yahoo.co.id

Wenny Rosalina
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Baiturrahmah, Padang, Indonesia
Online First: August 01, 2020 | Cite this Article
Ismardianita, E., Rosalina, W. 2020. Acceleration of granulation tissue using myrmecodiapendens extract induction during wound healing tooth extraction process (experimental research on caviacobaya). Journal of Dentomaxillofacial Science 5(2): 124-128. DOI:10.15562/jdmfs.v5i2.1071


Objective:To identify the effect of myrmecodiapendens extract 20% on granulation tissue post-tooth extraction.

Material and Methods: Twenty-four caviacobaya divided into two groups: the control group and treatment group. Lower left incisor tooth subjects were extracted and the entire socket filled with CMC 0.5% in the control group and myrmecodiapendens extract 20% in the treatment group, 0.1 CC in each subject. On days 3, 7, 14, and 21 subjects were determined, subsequently, socket tissues were stained with Haematoxylin Eosin (HE) technique. Angiogenesis, fibroblast, and macrophage were used to evaluated granulation tissue on wound healing post-tooth extraction. Data were analyzed with the Kruskal-Wallis test to see differences between the control group and treatment group with a level of significant p <0.05.

Results: This study indicates significant differences in angiogenesis, fibroblast, and macrophage between control group and treatment group (p <0.05).

Conclusion: This study confirmed the effect of myrmecodiapendens extract 20% increase angiogenesis, fibroblast, and macrophage, which is can improve wound healing process post-tooth extraction.

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