Original Article

Changes in osteoblast and osteoclast cell count after moringa oleifera leaf extract administration during orthodontic tooth movement

Rika D. Syarif , Tuti Kusumaningsih, Ira Arundina

Rika D. Syarif
Department of Orthodontic, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia. Email: rik.damayanti17@gmail.com

Tuti Kusumaningsih
Department of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia

Ira Arundina
Department of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
Online First: August 01, 2020 | Cite this Article
Syarif, R., Kusumaningsih, T., Arundina, I. 2020. Changes in osteoblast and osteoclast cell count after moringa oleifera leaf extract administration during orthodontic tooth movement. Journal of Dentomaxillofacial Science 5(2): 98-102. DOI:10.15562/jdmfs.v5i2.1081


Objective: The aim of this study was to analyze the effect of moringa leaf extract administration at 5%, 10%, and 20% concentration toward osteoblast and osteoclast cell count in tension area of Cavia cobaya tooth movement.

Matrial and Methods: This study was an experimental research with post test only control group design conducted on Cavia Cobaya. The samples were divided into 4 groups, namely control group (given orthodontic forces), P1 group (given orthodontic forces and Moringa oleifera extract at 5% concentration), P2 group (given orthodontic forces and Moringa oleifera extract at 10% concentration) and P3 group (given orthodontic forces and Moringa oleifera extract at 20% concentration). The samples were sacrificed in day 15 and the tissue were collected for histological examination to examine osteoblast and osteoclast cell count.

Results: The Anova test showed a significant difference of osteoblast and osteoclast cell count among groups (p<0.05).

Conclusion: Moringa leaves extract administration at 20% concentration for 7 days shows higher number of osteoblast and osteoclast compared to control group, 5% and 10% extract group.

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