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  • Gostry A. Dohude ,
  • Mulyani Rahmah ,


AbstractAim : This study aims to determine the effectiveness of lidocaine of local anaesthetic agent in inhibiting the growth of Streptococcus mutans bacteria.Material and Methods : This type of research is a laboratory experimental with a post test only control group design. Microorganism used was Streptococcus mutans and cultured at the Microbiology Laboratory of the Pharmacy, Universitas Sumatera Utara. The local anaesthetic tested was a solution of lidocaine diluted with NaCl 0,9% to 0,5%, 1%, and  2%. The antibacterial activity test was carried out using diffusion method by dripping 25 µl of lidocaine (0,5%, 1%, 2%), positive control (amoxicillin), and negative control (NaCl 0,9%) on disc paper, then placed on nutrient agar, and incubated. After 24 hours, the inhibition zone formed around the disc paper was observed.Results : Lidocaine showed antibacterial activity with the inhibition zone of 0,5%, 1%, 2% concentration was 6,98 mm, 7,66 mm, 8,36 mm. Then the data was analyzed using the One-way ANOVA test. From these results, there was a significant difference in the mean of the inhibitin zone (p < 0,05) between 0,5%, 1%, and 2% lidocaine, positive control, and negative control.Conclusion : Lidocaine has antibacterial activity against Streptococcus mutans bacteria with an effective concentration of 2%.


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How to Cite

Dohude, G. A., & Rahmah, M. . (2022). LOCAL ANAESTHETIC INHIBITION OF LIDOCAINE ON THE GROWTH OF STREPTOCOCCUS MUTANS IN VITRO. Journal of Dentomaxillofacial Science, 7(2).




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