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Periodontitis correlated with increased ESR and platelet counts in Indonesians with type 2 diabetes mellitus

  • Hendri Susanto ,
  • Frank Abbas ,


Abstract

Background : Periodontitis increases systemic inflammation in type 2 diabetes mellitus (DM2). Platelet count may be increased in periodontitis. The increased systemic inflammation and platelet counts are considered risk factors for atherosclerosis. However, there was no study investigating the correlation between periodontitis and platelet counts in type 2 diabetes mellitus in Indonesians. Objective: To assess the correlation between periodontitis, systemic inflammatory markers and platelet counts in Indonesian DM2 patients.   Methods: A full mouth periodontal examination including bleeding on probing, probing pocket depth, gingival recession, and plaque scores was performed in Indonesians DM2 in Dr. Sardjito Hospital, Yogyakarta. Indonesia. In addition, glycated hemoglobin (HbA1c), erythrocyte sedimentation rates (ESR), High sensitivity C reactive protein (Hs-CRP), peripheral blood counts, were assessed. To assess age, body mass index (BMI) education level, ethnicity, sex/gender, smoking, a standardized questionnaire was used and presented descriptively. In correlation and multiple linear regression analyses, it was assessed whether periodontitis operationalized with periodontal inflamed surface area (PISA) correlated with systemic inflammatory markers (Hs-CRP, ESR), HbA1c and peripheral blood counts (hemoglobin, leucocytes, erythrocytes, platelets, hematocrite) with 95% Confidence Interval.Results: In 44 Indonesians treated for DM2, PISA was associated with ESR (r = 0.32; p<0.05), and platelet count (r = 0.527; p < 0.05). Plaque score and PISA were the predictors for platelet count (p<0.05)Conclusion: Periodontitis Is associated with increased the systemic inflammation marker Erythrocyte Sedimentation Rate (ESR) and platelet counts in Indonesians DM2 and therefore may form an additional risk factor for atherosclerosis in these patients.
Keywords: Periodontitis (MeSH) PISA type 2 diabetes mellitus (MeSH) ESR platelet count (MeSH)
Section

References

  1. Reference
  2. Procopiou M, Philippe J. The metabolic syndrome and type 2 diabetes: Epidemiological figures and country specificities. Cerebrovasc Dis. 2005;20(SUPPL. 1):2-8. doi:10.1159/000088231
  3. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27(5):1047-1053.
  4. Susanto H, Nesse W, Dijkstra PUU, Agustina D, Vissink A, Abbas F. Periodontitis Prevalence and Severity in Indonesians With Type 2 Diabetes. J Periodontol. 2010;82(4):550-557. doi:10.1902/jop.2010.100285
  5. Bascones-Martinez A, Matesanz-Perez P, Escribano-Bermejo M, González-Moles MÁ, Bascones-Ilundain J, Meurman JH. Periodontal disease and diabetes-Review of the literature. Med Oral Patol Oral Cir Bucal. 2011;16(6):722-729. doi:10.4317/medoral.17032
  6. Nitta H, Katagiri S, Nagasawa T, et al. The number of microvascular complications is associated with an increased risk for severity of periodontitis in type 2 diabetes patients: Results of a multicenter hospital-based cross-sectional study. J Diabetes Investig. 2017;8(5):677-686. doi:10.1111/jdi.12633
  7. Liccardo D, Cannavo A, Spagnuolo G, et al. Periodontal disease: A risk factor for diabetes and cardiovascular disease. Int J Mol Sci. 2019;20(6). doi:10.3390/ijms20061414
  8. Paraskevas S, Huizinga JD, Loos BG. A systematic review and meta-analyses on C-reactive protein in relation to periodontitis. J Clin Periodontol. 2008;35(4):277-290. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18294231
  9. King DE, Mainous AG, Buchanan TA, Pearson WS. C-reactive protein and glycemic control in adults with diabetes. Diabetes Care. 2003;26(5):1535-1539. doi:10.2337/diacare.26.5.1535
  10. Susanto H, Nesse W, Dijkstra PU, et al. Periodontal inflamed surface area and C-reactive protein as predictors of HbA1c: a study in Indonesia. Clin Oral Investig. 2012;16(4):1237-1242. doi:10.1007/s00784-011-0621-0
  11. Rahman AU, Rashid S, Noon R, et al. Prospective evaluation of the systemic inflammatory marker C-reactive protein in patients with end-stage periodontitis getting teeth replaced with dental implants: a pilot investigation. Clin Oral Implant Res. 2005;16(1):128-131. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15642040
  12. Blum A, Front E, Peleg A. Periodontal care may improve systemic inflammation. Clin Invest Med. 2007;30(3):E114-7. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17716549
  13. Teeuw WJ, Slot DE, Susanto H, et al. Treatment of periodontitis improves the atherosclerotic profile: A systematic review and meta-analysis. J Clin Periodontol. 2014;41(1). doi:10.1111/jcpe.12171
  14. Wang Y, Yang P, Yan Z, et al. Review Article The Relationship between Erythrocytes and Diabetes Mellitus. 2021;2021.
  15. Siddeshappa S, Nagdeve S, Yeltiwar R, Parvez H, Deonani S, Diwan V. Evaluation of various hematological parameters in patients with periodontitis after nonsurgical therapy at different intervals. J Indian Soc Periodontol. 2016;20(2):180-183. doi:10.4103/0972-124X.175172
  16. Romandini M, Laforí A, Romandini P, Baima G, Cordaro M. Periodontitis and platelet count: A new potential link with cardiovascular and other systemic inflammatory diseases. J Clin Periodontol. 2018;45(11):1299-1310. doi:10.1111/jcpe.13004
  17. Diabetes DOF. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2010;33 Suppl 1:S62-9. doi:10.2337/dc10-S062
  18. Abraham-Inpijn L, Russell G, Abraham D a, et al. A patient-administered Medical Risk Related History questionnaire (EMRRH) for use in 10 European countries (multicenter trial). Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105(5):597-605. doi:10.1016/j.tripleo.2007.09.032
  19. Susin C, Kingmasn Al, Albandar JM. Effect of partial recording protocols on estimates of Prevalence of periodontal disease. J Clin Periodontol. 2008;35(8):659-667. doi:10.1111/j.1600-051X.2008.01243.x
  20. Hugoson A, Norderyd O. Has the prevalence of periodontitis changed during the last 30 years? J Clin Periodontol. 2008;35(8 Suppl):338-345.
  21. Bmi WHO, Bmi TWHO. Public health Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. 2004;363:157-163.
  22. Indurkar MS, Maurya AS, Indurkar S. Oral manifestations of diabetes. Clin Diabetes. 2016;34(1):54-57. doi:10.2337/diaclin.34.1.54
  23. Haral L. Periodontal Disease: The sixth complication of diabetes mellitus. Diabetes Care. 1993;16(1):329-334.
  24. Wu CZ, Yuan YH, Liu HH, et al. Epidemiologic relationship between periodontitis and type 2 diabetes mellitus. BMC Oral Health. 2020;20(1):1-15. doi:10.1186/s12903-020-01180-w
  25. Yeh ETH. High-sensitivity C-reactive protein as a risk assessment tool for cardiovascular disease. Clin Cardiol. 2005;28(9):408-412. doi:10.1002/clc.4960280905
  26. Bertoluci MC, Rocha VZ. Cardiovascular risk assessment in patients with diabetes. Diabetol Metab Syndr. 2017;9(1):1-13. doi:10.1186/s13098-017-0225-1
  27. Soinio M, Marniemi J, Laakso M, Lehto S, R?onnemaa T. High-sensitivity C-reactive protein and coronary heart disease mortality in patients with type 2 diabetes: A 7-year follow-up study. Diabetes Care. 2006;29(2):329-333. doi:10.2337/diacare.29.02.06.dc05-1700
  28. Sanz M, Marco del Castillo A, Jepsen S, et al. Periodontitis and cardiovascular diseases. Consensus report. Glob Heart. 2020;15(1):1-23. doi:10.5334/GH.400
  29. Priyamvara A, Dey AK, Bandyopadhyay D, et al. Periodontal Inflammation and the Risk of Cardiovascular Disease. Curr Atheroscler Rep. 2020;22(7):20-25. doi:10.1007/s11883-020-00848-6
  30. Preshaw PM, Alba AL, Herrera D, et al. Periodontitis and diabetes: A two-way relationship. Diabetologia. 2012;55(1):21-31. doi:10.1007/s00125-011-2342-y
  31. Zhang DH, Yuan QN, Zabala PM, Zhang F, Ngo L, Darby IB. Diabetic and cardiovascular risk in patients diagnosed with periodontitis. Aust Dent J. 2015;60(4):455-462. doi:10.1111/adj.12253
  32. Katagiri S, Nitta H, Nagasawa T, et al. Multi-center intervention study on glycohemoglobin (HbA1c) and serum, high-sensitivity CRP (hs-CRP) after local anti-infectious periodontal treatment in type 2 diabetic patients with periodontal disease. Diabetes Res Clin Pract. 2009;83(3):308-315.
  33. Baeza M, Morales A, Cisterna C, et al. Effect of periodontal treatment in patients with periodontitis and diabetes: Systematic review and meta-analysis. J Appl Oral Sci. 2020;28:1-13. doi:10.1590/1678-7757-2019-0248
  34. Wang X, Meng HX, Xu L, Chen Z, Shi D, Lv D. Mean platelet volume as an inflammatory marker in patients with severe periodontitis. Platelets. 2015;26(1):67-71. doi:10.3109/09537104.2013.875137
  35. Nesse W, Abbas F, van der Ploeg I, Spijkervet FK, Dijkstra PU, Vissink A. Periodontal inflamed surface area: quantifying inflammatory burden. J Clin Periodontol. 2008;35(8):668-673.

How to Cite

Susanto, H., & Abbas, F. . (2022). Periodontitis correlated with increased ESR and platelet counts in Indonesians with type 2 diabetes mellitus. Journal of Dentomaxillofacial Science, 7(1), 39–43. https://doi.org/10.15562/jdmfs.v7i1.1249
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