Cervical margin of fixed denture either jacket crown or bridge, is usually placed
subgingivally for the natural look, however this can sometimes cause gingival
inflammation. Moreover, if the restoration material is acrylic, it sometimes can irritate
oral tissue. The aim of this study was to investigate the effect of acrylic, used as fixed
denture material, to gingival tissue reaction. This was an experimental study, using pre
and post test of 5 acrylic jacket crowns, made to patients in the Prosthodontic
Department, Dental Hospital of Hasanuddin University. Gingival crevicular fluid (GCF)
was collected before preparation, and three weeks after insertion of the jacket crowns,
then pro-inflammatory cytokines; TNF-α and IL-1β were examined. The results analyzed
by Wilcoxon sign rank test (p<0.05). The results showed the elevation of TNF-α and IL1β

concentration after acrylic jacket crown insertion compare with the concentration
before preparation. The conclusion of this study is acrylic restoration material may cause
gingival inflammation.

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