Case Report

Stomatitis aftosa rekuren oleh karena anemia

Maharani Laillyza Apriasari , Hening Tuti

Maharani Laillyza Apriasari
Ilmu Penyakit Mulut Fakultas Kedokteran Gigi Universitas Airlangga Surabaya, Indonesia. Email:

Hening Tuti
Bagian Ilmu Penyakit Mulut Fakultas Kedokteran Gigi Universitas Airlangga Surabaya, Indonesia
Online First: April 30, 2010 | Cite this Article
Apriasari, M., Tuti, H. 2010. Stomatitis aftosa rekuren oleh karena anemia. Journal of Dentomaxillofacial Science 9(1): 39-46.

Recurrent aphthous stomatitis (RAS) is the common lesion in oral cavity. The etiology
of RAS remains unclear. The trigger factors are genetic, traumatic, abnormal
immunology, digestive diseases, hormonal disturbance, HIV, stress, infection and
nutrition deficiency. This is a case report of a patient with minor, multiple, pain, white
color ulcer with erythema halo on lips palatum and tongue mucous. One day before
the ulcers erupted, prodromal symptoms had occurred such as subfebris, malaise, and
dizziness. The patient was 19-year-old, male, undergraduate student and with history
of ulceration every month. The clinical diagnosis was primary herpetic
gingivostomatitis. The differential diagnosis was RAS. The complete blood count
(CBC) result indicated that the patient suffered anemia. He was provided with
benzydamin HCl gargle and oral supplement contain ferrous, vitamins, and minerals.
It can be concluded that anemia can be a trigger factor of RAS. Therefore, it is
important for the dentist to know the clinical signs and manifestations of anemia in
oral cavity in order to provide an appropriate treatment.


Laskaris G. Treatment of oral disease : A concise textbook. Thieme; 2005. p. 15-7.

Field A, Longman L. Tyldesley’s oral medicine, 5th Ed. Oxford; 2004. p. 154-6.

Cawson RA, Odell EW. Cawson’s essentials of oral pathology and oral medicine, 7 Ed. Churchill Livingstone; 2002. p. 294-5.

Wray D, Lowe D, Felix, Scully. Textbook of general and oral medicine. Churchill Livingstone; 2001. p. 225-32.

Greenberg G. Burket’s oral medicine diagnosis and treatment, 10th

Ed. BC Decker Inc; 2003. p. 430-2.

Moreno, Villalpando, Shamah. Anemia. National Public Health Institute, Autonomous University of Yucatan. Mexico: Elsevier Inc; 2008. p. 174-83.

Ciesla B. Hematology in practice. Philadelphia: FA Davis Company; 2007. p.66-70.

Neville D, Allen B. Oral and maxillofacial pathology,2nd Ed. WB.Saunders;2002.p.285-6.

Kus Harijanti, Mintarsih. Candidosis on oral lichenplanus. Dent J (Majalah Kedokteran Gigi)2006; 39 April-June:

Griffth III, Hoelein, Feddock H. First exposure internal medicine: hospital medicine, Mc Graw-Hill Companies, Inc, 2007 ; p. 3735

Hong-Cheng Wu, Shin-Yu Lu. Initial diagnosis of anemia from sore mouth and improved classification of anemia by MCV

and RDW in 30 patients. Director of Oral Medicine and Oral Diagnosis, Chang Gung Memorial Hospital. Kaohsiung Medical Center, Taiwan: Elsevier Inc, 2004; p. 679-84

Habbermann G. Mayo clinic internal medicine concise textbook. Mayo Clinic Scientific Press; 2008. p. 347-8

Silverman, Eversole, Truelove. Essentials of oral medicine. BC Decker Inc; 2001. p. 67-70

Beard JL. Iron biology in immune function, muscle metabolism and neuronal functioning.

american society for nutritional sciences, Pennsylvania: State University; 2001. p. 4-5.

Hunt JR. Iron, USDA-ARS grand forks human nutrition research center, Grand Forks: Elsevier Ltd; 2005. p. 82-9.

No Supplementary Material available for this article.
Article Views      : 8441
PDF Downloads : 8341