Skip to main content Skip to main navigation menu Skip to site footer

Peran prostaglandin pada pergerakan gigi ortodontik

Abstract

Orthodontic tooth movement is a complex process, in which cellular and chemicalchanges occur. When a force is applied onto a tooth, it causes tissue injury,compression of periodontal ligament and bone deformation. These procedures lead tofollowed by certain biochemical reactions at cellular level which results in boneremodeling. Thus a process of signal transduction occurs. In this process, somemessengers are released, including prostaglandin. Prostaglandin is an arachidonicacid metabolite, released when cell membrane is deformed. Prostaglandin,particularly PGE, play a role in bone metabolism and orthodontic tooth movement.Prostaglandin will stimulate the release of second messengers, i.e. cAMP and calciumintracellular. These second messengers will activate osteoclasts. Prostaglandin willalso induce RANKL (receptor activator of nuclear factor κβ ligand) to initiateosteoclasts differentiation. Some researchers proved that application of prostaglandinin orthodontic treatment can accelerate tooth movement.
Section

References

  1. Proffit WR. Contemporary orthodontics. 4 ed. St. Louis: Mosby Elsevier; 2007.p.331-43. 2. Singh G. Texbook of orthodontics. New
  2. Delhi: Jaypee Brothers Medical Publisher; 2004. p.198-204.
  3. Bhalajhi SI. Orthodontics:The art and science. 3rd ed. New Delhi: Arya (MEDI) Publishing House; 2006. p.181-94.
  4. Foster TD. Buku ajar ortodonsi. Edisi 3. Alih bahasa:Yuwono L.Jakarta:EGC;1997.p.168-85.
  5. Meikle MC. The tissue, cellular, and molecular regulation of orthodontic tooth movement: 100 years after Carl Sandstedt. Eur J Orthod 2006; 28: 221-40.
  6. Mulyani. Biomekanik pergerakan gigi. Jakarta: Widya Medika; 1994. p.29-48.
  7. Masella RS, Meister M. Current concepts in the biology of orthodontic tooth movement. Am J Orthod Dentofac Orthop 2006; 129: 458-68.
  8. Valiathan A, Dhar S. Prostaglandin and enhanced orthodontic tooth movement: in search of the silver bullet. Current Sci 2006;90: 311-3.
  9. Yamasaki K, Shibata Y, Fukuhara T. The effect of prostaglandin on experimental tooth movement in monkeys (Macaca fuscata). J Dent Res 1982; 12: 1444-6.
  10. Cardaropoli D, Gaveglio L. The influence of orthodontic movement on periodontal tissues level. Semin Orthod 2007; 13: 234-45.
  11. Yamasaki K, Shibasaki Y, Fukuhara T. Behavior of mast cells in periodontal ligament associated with experimental tooth movement
  12. in rats. J Dent Res 1982; 61: 1447-50.th
  13. Nanda R. Biomechanics and esthetic strategies in clinical orthodontics. St. Louis: Elsevier Saunders; 2005. p.17-27. 13. Smith JB. Prostaglandin and related eicosanoids. In: DiPalma JR, DiGregorio GJ(Ed). Basic pharmacology in medicine. 3ed. New York: McGraw-Hill Publishing Company; 1990. p.181-7.
  14. Ganong WF. Buku ajar fisiologi kedokteran. Ed 17. Alih bahasa: Widjajakusumah MD. Jakarta: EGC; 1998. p.303-5, 376-88.
  15. Bartzela T, Türp JC, Motschall E, Maltha JC. Medication effects on the rate of orthodontic tooth movement: a systematic literature
  16. review. Am J Orthod Dentofac Orthop 2009; 135: 16-26.
  17. Sandy JR, Farndale RW, Meikle MC. Recent advances in understanding mechanically induced bone remodeling and their relevance to orthodontic theory and practice. Am J Orthod Dentofac Orthop 1993; 103: 212-22.
  18. Lieberman M, Marks A. Mark’s basic medical biochemistry: a clinical approach. 3ed. Philadelphia: Lippincott Williams and Wilkins; 2009. p.671-84.
  19. Foegh ML, Ramwell PW. The eicosanoids: Prostaglandins, thromboxanes, leukotrines, and related compounds. In: Katzung BG (Ed). Basic and clinical pharmacology. 9th ed. New York: The McGraw-Hill Companies; 2004. p.298-312.
  20. Pilbeam CC, Harrison JR, Raisz LG. Prostaglandin and bone metabolism. In: Bilezikian JP, Raisz LG, Rodan GA (Ed). Principles of bone biology. San Diego: American Press,Inc.; 1996. p.715-22.
  21. Ilyina A, Alvarado GD, Trimmer RE, Garcia LMG, Villarreal SJA, Martinez HJL, dkk. Comparative study of the effects of administration of PGE 1 , PGE , and enzymatic preparation with prostaglandin h-synthase
  22. activity on orthodontic tooth movement. Biocatalysis 2000; 41: 81-4.2
  23. Raisz LG. Physiologic and pathologic roles of prostaglandins and other eicosanoids in bone metabolism. J Nutr 1995; 125: 2024S-7S.
  24. Fracon RN. Teofilo JM. Satin RB, Lamano T. Prostaglandins and bone: Potential risks andrdrd benefits related to the use of nonsteroidal antiinflammatory drugs in clinical dentistry. J Oral Sci 2008; 50: 247-52.
  25. Yamasaki K, Shibata Y, Imai S, Tani Y, Shibasaki Y, Fukuhara T. Clinical application of prostaglandin E upon orthodontic tooth
  26. movement. Am J Orthod 1984; 85: 508-18.1
  27. Machwate M, Harada S, Leu CT, et al. Prostaglandin receptor EP4 mediates the bone anabolic effects of PGE. Mol Pharmacol 2001;60:36-41.2
  28. Yamasaki K, Miura F, Suda T. Prostaglandin as a mediator of bone resorption indiced by experimental tooth movement in rats. J Dent
  29. Res 1980; 59: 1635-42.
  30. Niaki EA, Yazdi E, Zamani A. The effects of PGE and indomethacin on orthodontic tooth movement in rat. Acta Medica Iranica 1999;37: 215-9.1
  31. Chumbley AB, Tuncay OC. The effect of indomethacin (an aspirin-like drug) on the rateof orthodontic tooth movement. Am J Orthod 1986; 89: 312-14.
  32. Lee W. Experimental study of the effect of prostaglandin administration on tooth movement-with particular emphasis on the
  33. relationship to the method of PGE administration. Am J Orthod Dentofac Orthop 1990; 98: 231-41.
  34. Kehoe MJ, Cohen SM, Zarrinnia K, Cowan A. The effect of acetaminophen, ibuprofen, and misoprostol on prostaglandin E
  35. synthesis and the degree and rate of orthodontic tooth movement. Angle Orthod 1996; 66: 339-50.
  36. Polat O. Pain and discomfort after orthodontic appointments.Semin Orthod 2007;13:292-300.
  37. Leiker BJ, Nanda RS, Currier GF, Howes RI, Sinha PK. The effects of exogenous prostaglandins on orthodontic tooth movements in rats. Am J Orthod Dentofacial Orthop 1995; 108: 380-8.
  38. Sekhavat AR, Mousavizadeh K, Pakshir HR, Aslani FS. Effect of misoprostol, a prostaglandin E analog, on orthodontic tooth movement in rats. Am J Orthod Dentofac Orthop 2002; 122: 542-7.

How to Cite

Iskandar, P., & Ismaniati, N. A. (2010). Peran prostaglandin pada pergerakan gigi ortodontik. Journal of Dentomaxillofacial Science, 9(2), 92–100. https://doi.org/10.15562/jdmfs.v9i2.238

HTML
510

Total
4870

Share

Search Panel