A Systematic Review

Peran prostaglandin pada pergerakan gigi ortodontik

Patricia Iskandar , Nia Ayu Ismaniati

Patricia Iskandar
Dokter Gigi Spesialis Ortodonti Fakultas Kedokteran Gigi, Universitas Indonesia Jakarta Pusat, Indonesia. Email: p4t05@yahoo.com

Nia Ayu Ismaniati
Departemen Ortodonti Fakultas Kedokteran Gigi, Universitas Indonesia Jakarta Pusat, Indonesia
Online First: April 30, 2010 | Cite this Article
Iskandar, P., Ismaniati, N. 2010. Peran prostaglandin pada pergerakan gigi ortodontik. Journal of Dentomaxillofacial Science 9(2): 92-100.


Orthodontic tooth movement is a complex process, in which cellular and chemical
changes occur. When a force is applied onto a tooth, it causes tissue injury,
compression of periodontal ligament and bone deformation. These procedures lead to
followed by certain biochemical reactions at cellular level which results in bone
remodeling. Thus a process of signal transduction occurs. In this process, some
messengers are released, including prostaglandin. Prostaglandin is an arachidonic
acid metabolite, released when cell membrane is deformed. Prostaglandin,
particularly PGE
, play a role in bone metabolism and orthodontic tooth movement.
Prostaglandin will stimulate the release of second messengers, i.e. cAMP and calcium
intracellular. These second messengers will activate osteoclasts. Prostaglandin will
also induce RANKL (receptor activator of nuclear factor κβ ligand) to initiate
osteoclasts differentiation. Some researchers proved that application of prostaglandin
in orthodontic treatment can accelerate tooth movement.

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