Original Article

Bagian Biomedis Fakultas Kedokteran Gigi, Universitas Jember Jember, Indonesia

I Dewa Ayu Ratna Dewanti

I Dewa Ayu Ratna Dewanti
Bagian Biomedis Fakultas Kedokteran Gigi, Universitas Jember Jember, Indonesia. Email: dewadewanti@yahoo.com
Online First: February 28, 2011 | Cite this Article
Dewanti, I. 2011. Bagian Biomedis Fakultas Kedokteran Gigi, Universitas Jember Jember, Indonesia. Journal of Dentomaxillofacial Science 10(1): 26-31.

Neem is one of the traditional medicine known by society as immunomodulator. On the other hand, 80% of oral
infection diseases is caused by C. albicans. This research is aimed to explain the phagocytosis activities on wistar
rats which were inoculated with C. albicans and fed with neem leaves. There are 5 groups, namely control group
(KO)with no treatment, the other treatment groups were classified into 4 groups. First group (KP1)was inoculated
with C. albicans only. KP2 was fed with 50 mg/day/kg BW aqueous extracts from neem leaves, then inoculated with
C. albicans start from day 8-21. KP3 was fed with 100 mg/day/kg BW aqueous extract from neem leaves, then
inoculated with C. albicans start from day 8-21. KP4 was fed with 200 mg/day/kg BW aqueous extract from neem
leaves, then inoculated with C. albicans start from day 8-21. On day 22, the tongue was swabbed for each group,
then cut for immunohistochemistry preparation. The study that there was significant difference showed that there
were different results computed using anova, HSD test, and linier regression. The conclusion was neem leaves
increased the phagocytosis activity of wistar rats, inoculated with C.albicans.


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