Original Article

Identifikasi Pseudomonas aeruginosa dan tes sensitivitas siprofloksasin pada abses periodontal Identification of Pseudomonas aeruginosa and sensitivity test of ciprofloxacin on periodontal abcess

Irene E. Rieuwpassa , Muliaty Yunus, I Wayan Suka Arsana

Irene E. Rieuwpassa
Bagian Biologi Oral Fakultas Kedokteran Gigi Universitas Hasanuddin Makassar. Email: drgirene@yahoo.com

Muliaty Yunus
Bagian Radiologi Fakultas Kedokteran Gigi Universitas Hasanuddin Makassar

I Wayan Suka Arsana
epartemen Bedah Umum RS Labuang Baji Makassar, Indonesia
Online First: October 30, 2011 | Cite this Article
Rieuwpassa, I., Yunus, M., Arsana, I. 2011. Identifikasi Pseudomonas aeruginosa dan tes sensitivitas siprofloksasin pada abses periodontal Identification of Pseudomonas aeruginosa and sensitivity test of ciprofloxacin on periodontal abcess. Journal of Dentomaxillofacial Science 10(3): 151-155.


Periodontitis is a common type of periodontal disease caused by expansion of the early stages of gingival
inflammation. Expansion of inflammation to the tissue structures supporting the teeth can be modified by the
pathogenic ability of plaque or host resistance factors. A total of 200 different bacteria have been identified on the
plaque. Resistance to antimicrobials can be natural because the microbes develop mechanisms to defend
themselves. Ciprofloxacin is a synthetic drug of the second generation quinolones derivatives. Mechanism of its
action is to inhibit the activity of bacterial DNA gyrase, which is bactericidal with a broad spectrum against Grampositive

or negative. This observational study identified P. aeruginosa and sensitivity test was performed to
ciprofloxacin in periodontal abscesses. Study conducted in 23 patients with periodontal abscess. Of those,
Pseudomonas was acquired for 8 samples and 4 of them was resistant to ciprofloxacin.

References

Ronderos M, Michalowicz B, Camara R, Contreras A. Bacterial and viral risk markers for juvenile periodontitis. J Periodontol 2000; 71: 1208.

Burt BA. Epidemiology of periodontal disease. J Periodontol 1996; 67:935-45.

Corbert EF, Wong MCM, Lin HC. Periodontal attachment loss in adult in Guandong RRC. J Dent Res 1997; 5: 1176-50.

Eick S, Schmitt A, Sachse S. In vitro antibacterial activity of fluoroquinolones against Porphyromonas gingivalis strains. J Antimicrob Chemother 2004;54(2): 553-6.

Brooks GF, Butel SJ, Morse SA. Mikrobiologi Kedokteran. Editor: Elferra RN. Alih bahasa: Hertanto H. Jakarta: Salemba Medika; 2007.

Depkes RI. Standar operating procedure (SOP) in microbiology. Jakarta: Laboratoriun Kesehatan Departemen Kesehatan; 2000.

Nord CE, Sjoberg L, Wadstrom T. Pseudomonas aeruginosa in oral Infections. Acta Odontol Scand 1972; 30: 371-81.

Sweeney LC, Dave J. Antibiotic resistance in general dental practice - a cause for concern? J Antimicrob Chemother 2004; 53(4): 567-76.

Rieuwpassa I.E, Hatta M. Deteksi mutasi gen gyrase A Porphyromonas gingivalis resisten terhadap ciprofloxacin berdasarkan teknik Polymerase Chain Reaction. Jurnal Kedokteran YARSI 2010; 17: 11-20. Irene E Rieupass, dkk: Identifikasi Pseudomonas aeruginosa dan tes sensitivitas siprofloksasin

Axelrod P, Tronstad L, Slots J. Ciprofloxacin treatment of periapical Pseudomonas aeruginosa infection. Philadelphia: Department of Endodontics; 1988.

Kim Y, Baik H. Topoisomerase II and topoisomerase iv gene mutations fluoroquinolone resistance of Pseudomonas aeruginosa. J Exp

Biomed Sci 2004; 10: 507-14.

Rieuwpassa IE, Ruslin M. Correlation between mutation in gene topoisomerase II (gyrase A) with ciprofloxacin resistance test in Pseudomonas aeruginosa. Abstract book of Asian Congres Oral &

Maxillofacial Surgery IX, Malaysia, November 2528,2010.

Lee JK, Lee YS, Park YK, Kim BS. Alterations in the GyrA and GyrB subunits of topoisomerase II and the ParC and ParE subunits of topoisomerase IV in ciprofloxacin-resistant clinical isolates of

Pseudomonas aeruginosa. Int J Antimicrob Agents 2005; 25: 290-5.

Ito J, Shirakawa T, Hatta M, Kinoshita S, Gotoh A, Kawabata M. Relationship between expression of multi-component type of efflux pumps, mutations in topoisomerase II and IV, and drug resistance to ciprofloxacin in Pseudomonas aeruginosa. BMC Research. 2006

Gabastou JM, Chouaki T, Mangeot J, Zemir A, Manuel C, Lepitre M, dkk. Phenotypes of resistance to antibiotics of the most frequently isolated strains in five specialized hospital centers. Multicenter

study. Pathol Biol 1995; 43 (4): 320-3. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgicmd=Retrieve&db=Pubed&list. Diakses 31 Mei 2006.


No Supplementary Material available for this article.
Article Views      : 2585
PDF Downloads : 2513