Original Article

Jumlah sel makrofag gingiva tikus wistar jantan yang diinduksi periodontitis setelah pemberian ekstrak etanolik kulit manggis Amount of machropahges cells in periodontitis-induced wistar rats after mangosteen rind etanolic extract administration

Rendra Chriestedy Prasetya

Rendra Chriestedy Prasetya
Bagian Biomedis Fakultas Kedokteran Gigi Universitas Jember Jember, Indonesia. Email: rendrachriestedy@gmail.com
Online First: October 30, 2013 | Cite this Article
Prasetya, R. 2013. Jumlah sel makrofag gingiva tikus wistar jantan yang diinduksi periodontitis setelah pemberian ekstrak etanolik kulit manggis Amount of machropahges cells in periodontitis-induced wistar rats after mangosteen rind etanolic extract administration. Journal of Dentomaxillofacial Science 12(3): 135-138.


Periodontitis is characterized with macrophages infiltration that is used to fagocyt bacteria which infiltrated at
gingiva. Mangosteen rind contains xantone, an anti-inflammatory substance which inhibits the synthesis of PGE2 and
therefore reduce inflammatory cells infiltration. This research aimed to study machropahges cells infiltration in
periodontitis-induced wistar rats after administration of mangosteen rind etanolic extract. Forty eight male wistar rats
were induced periodontitis for 7 days. After the ligation was taken out, the rats were divided into 4 groups, and treated
orally with mangosteen rind extract 60 mg/kg BB, 30 mg/kg BB, ibuprofen and saline. The rats were sacrified on the 1st, 3rd, 4th, and 7th day after the treatment. Their anterior lower jaws were processed histologically and stained with
hematoxylin eosin. Two-way anova test showed a significant difference among groups (p<0.05). It was concluded that
mangosteen rind etanolic extract reduced the number of macropaghes cells gingiva in periodontitis male wistar rats.

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