Original Article

Efek pegagan (Centella asiatica L)terhadap proliferasi mesenchymal stem cell (Effect of pegagan (Centella asiatica L)to mesenchymal stem cell proliferation)

Ira Arundina , Ketut Suardita

Ira Arundina
Department of Oral Biology Faculty of Dentistry, Airlangga University Surabaya, Indonesia. Email: arundinafkg@yahoo.com

Ketut Suardita
Department of Dental Conservative Faculty of Dentistry, Airlangga University Surabaya, Indonesia
Online First: February 28, 2014 | Cite this Article
Arundina, I., Suardita, K. 2014. Efek pegagan (Centella asiatica L)terhadap proliferasi mesenchymal stem cell (Effect of pegagan (Centella asiatica L)to mesenchymal stem cell proliferation). Journal of Dentomaxillofacial Science 13(1): 43-47. DOI:10.15562/jdmfs.v13i1.386


Stem cells provide new hope to fasten the healing process of various oral diseases including periodontal tissue
(periodontitis). At present time, there is not yet found a material that can fix the teeth perfectly. Adult stem cells from
bone marrow widely used for treatment. Numbers of stem cell are limited so growth factor is necessary to promote
proliferation of stem cells. Growth factor that has been used is expensive and difficult to get. Because of these
constraints, it is necessary to develop alternative uses of medicinal plants as growth factor that accelerates wound
healing process. This study is aimed to proven what extent the potential Pegagan (Centella asiatica L) as a natural
growth factors to stem cells. The ability of proliferation and osteogenic differentiation in mesenchymal stem cells
(MSC)was analyzed by adding terpenoid fraction of Centella asiatica. MTT assay data showed that the addition of
Pegagan on cultured MSCs can increase stem cell proliferation. Pegagan increases the ability of MSC proliferation
and differentiate into osteoblasts It is concluded that pegagan increase the ability of MSC proliferation and
differentiate into osteoblasts.

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