Original Article

Esktrak ikan haruan (Channa striata) menurunkan jumlah makrofag pada fase inflamasi proses penyembuhan luka (Extract of haruan (Channa striata) decreases macrophages count in inflammation phase of wound healing process )

Putri Sri Hartini , Nurdiana Dewi, Lisda Hayatie

Putri Sri Hartini
Fakultas Kedokteran Universitas Lambung Mangkurat Banjarmasin, Indonesia. Email: putri.hrtn@yahoo.com

Nurdiana Dewi
Bagian Biologi Oral Program Studi Kedokteran Gigi Fakultas Kedokteran Universitas Lambung Mangkurat Banjarmasin, Indonesia

Lisda Hayatie
Bagian Parasit Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Lambung Mangkurat Banjarmasin, Indonesia
Online First: February 28, 2015 | Cite this Article
Hartini, P., Dewi, N., Hayatie, L. 2015. Esktrak ikan haruan (Channa striata) menurunkan jumlah makrofag pada fase inflamasi proses penyembuhan luka (Extract of haruan (Channa striata) decreases macrophages count in inflammation phase of wound healing process ). Journal of Dentomaxillofacial Science 14(1): 6-10. DOI:10.15562/jdmfs.v14i1.417


Haruan is a kind of freshwater fishes commonly found in South Kalimantan. Haruan extract contains nutritional substances
such as albumin, Zn, Fe, Cu, and unsaturated fatty acid which can help accelerate wound healing. The aim of this study
was to histopathologically assess the effect of 100%, 50%, and 25%haruan extract compared to aquadest and ibuprofen
on macrophages count in inflammation phase of wistar rats’ buccal mucosa wound healing. This research was a true
experimental with post test-only with control design. Samples used were 30 wistar rats divided into 5 groups, 100%, 50%,
25% haruan extract treatment groups, ibuprofen treatment group as positive control, and aquadest treatment group as
negative control. Mean macrophages counted on day 3 of 100%, 50%, 25% haruan extract treatment groups aquadest,
and ibuprofenl were 2.05, 4.4, 3.9, 3.3, 2.4 respectively. In conclusion, haruan extract had a significant effect in decreasing
macrophages count in inflammation phase of wound healing.

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