Efficacy of mengkudu leaves extract (morinda citrifolia) on wound healing rate post tooth extraction in white rats (rattus norvegicus)
Abstract
Objective:Â This study aims to determine the efficacy of mengkudu leaves extract to accelerate wound healing post tooth extraction in white rats.Material and Methods: Laboratory experimental study was carried out using post-test only and control group design. This study was measured by observing the duration of wound healing post tooth extraction, starting from the formation of sockets after tooth extraction until the socket closed, with sample of 27 white rats in three study groups in accordance with inclusion and exclusion criteria that have been determined.Results: The average healing time in the negative control group is 19 days, the positive control group is 9 days, and the treatment group with mengkudu leaves extract is 7 days. Therefore, the fastest time of wound healing occurs in the treatment group, followed by the positive control group and lastly, in the negative control group.Conclusion: Mengkudu leaves accelerate wound healing post tooth extraction in white male rats.
Section
References
- Oroh CG, Damajanty HC, Christy NM. Efektivitas lender bekicot (achatinafulica) terhadap jumlah sel fibroblast pada luka pasca pencabutan gigi tikus wistar. Jurnal e-Gigi 2015;3: 516.
- Adeyemo WL, Akinola LL, Mobolanie OO. Clinical evaluation of post-extraction site wound healing. J Contemp Dent Pract 2006;7: 40-49.
- Fragiskos FD. Peroperatif and postoperative complication. In Oral surgery. New York: Springer; 2007. p. 181
- Zulfa, Elly N, Dewi G. Perbandingan penyembuhan luka terbuka menggunakan balutan madu atau balutan normal saline-povidone iodine. Jurnal Keperawatan Indonesia 2008;12: 34-39.
- Suwiti NK. Deteksi histologic kesembuhan luka pada kulit pasca pemberian daun mengkudu (Morindacitrofilialinn). Buletin Veteriner Udayana 2010;2: 1-8.
- Daniel L. The development of anesthesiology in oral and maxillofacial surgery. Oral Maxillofac Surg Clin North Am 2013;25: 341-355.
- Sabirin IP, Ani MM, Bethy SH. Peran ekstrak etanol topical daun mengkudu (morindacitrifolia l.) pada penyembuhan luka ditinjau dari imunoekspresi CD34 dan kolagen pada tikus galur wistar. MKB 2013;45: 226-232.
- Yuslianti ER, Rahmayani LP, Afifah BS. Effectiveness of noni (morindacitrifolia l.) leave extract gel as standardized traditional medicine to accelerate oral mucosa wound healing on wistar rats. J Medical Plant 2014;8: 156-160.
- Tamales D, Dewi N, Rosida L. Extract of haruan (channa striata) extract increasing reepithelialisation count in wound healing process on wistar rat’s buccal mucosa. J Dentomaxillofac Sci 2016;1: 12-15.
- Rasal Vp, Arulmozhi S, Purnima A, et al. Wound healing and antioxidant activities of morinda citrifolia leaf extract in rats. J Pharmacol Ther 2007;7: 49-52.
- Yogesh S, Jeyabalan G, Ramandeep S, etal. Current aspects of wound healing agents from medicinal plants: a review. JMed Plants Stud 2013;1: 1-11.
- Assi RA, Yusrida D, Ibahim MA, et al. Morindacitrifolia (noni): a comprehensive review in its industrial uses, pharmacological activities and clinical trials. Arab J Chem 2017;10: 691-707.
- Güclü-Ustündağ O, Mazza G. Saponins: properties, applications and processing. Crit Rev Food Sci Nutr 2007;47: 231-258.
- Ismarani. Potensi senyawa tannin dalam menunjang produksi ramah lingkungan. CEFARS 2012;3: 46-55.
- Prochazkova D, Bousova I, Wilhelmova N. Antioxidant and prooxidant properties of flavonoids. Fitoterapia 2011;82: 513-523.
- Yuslianti ER, Sabirin IPR, Sovia E. Effect of topical ethanol extracts ofmorindacitrofiliaL. leaves on excisional wound healing.Int J Pharmacol 2013;9: 318-321.
- Brunetty C, Ferdinando M, Aliissio F, et al. Flavonoids as antioxidants and developmental regulators: relative significance in plants and humans. Int J Mol Sci 2013;14: 3540-3555.
- Agati G, Azzarello, Pollastri S, et al. Flavonoids as antioxidants in plants: location and functional significance. Plant Sci J 2012;196: 67-76.
- HernaÌndezI, Alegre L, Van-Breusegem F, et al. How relevant are flavonoids as antioxidants in plants. Trends Plant Sci 2009;14: 125-132.
How to Cite
Rasul, I., & Setiady, D. (2018). Efficacy of mengkudu leaves extract (morinda citrifolia) on wound healing rate post tooth extraction in white rats (rattus norvegicus). Journal of Dentomaxillofacial Science, 3(1), 28–31. https://doi.org/10.15562/jdmfs.v3i1.547