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Effect of ethanol extract of myrmecodia pendens on TGF-?1 expression and osteoblast cells after tooth extraction (experimental research on cavia cobaya)


Objective: Myrmecodia pendens is often used as a traditional medicine to treat various disease. A previous study, ethanol extract of sarang semut plant (Hypnophytum furmicarum jack) 4.65 mg was effective in fastening establishment of socket granulation tissue after tooth extraction, the Myrmecodia pendens 3% too fasten healing soft tissue of wound after tooth extraction. The aim of this study to determine the effect of ethanol extract of Myrmecodia pendens to the expression of TGF-β1, and the number of osteoblasts after tooth extraction.Material and Methods: this study using 24 male marmoots were divided into 2 groups. The entire groups had extract done 1st left incisor mandibula, into the socket control group applied 0,1 ml of 0.5% CMC and treatment group was given 0,1 ml of ethanol extract Myrmecodia pendens 10% dissolved with CMC 0.5%. On day 3,7,14 and 21, marmoots were decapitated and histopathologic preparations then observed the expression of TGF-β1, and the number of osteoblast cell. Data analyzed by Kruskall-wallis test with probability p<0.05 and Mann-Whitney to determine differences in effectiveness between variables.Results: Based on the Kruskal-wallis test, there is a significant difference the TGF-β1 expression and the number of osteoblast cell which had giving ethanol extract of Myrmecodia pendens between of control group and group treatment (p<0.05), further test with Mann-Whitney for TGF-β1 with days of observation shown a significant difference meanwhile osteoblast with days of observation showed no significant difference.Conclusion: the ethanol extract Myrmecodia pendans can assist the wound healing process after tooth extraction by increasing the expression of  TGF-β1, and osteoblast cells number


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How to Cite

Ismardianita, E., Nasrul, E., Yanwirasti, Y., & Hemiawati, M. (2017). Effect of ethanol extract of myrmecodia pendens on TGF-?1 expression and osteoblast cells after tooth extraction (experimental research on cavia cobaya). Journal of Dentomaxillofacial Science, 2(3), 150–154.




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