The correlation of consuming thymoquinone extract of nigella sativa to tooth socket re-epithelization on diabetic-induced rats
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Aug 1, 2018
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Abstract
Objective: The purpose of this research is to determine the effect of Tq to re-epithelialization at the margin of tooth socket post-extraction in diabetic rats.Material and Methods: Used 27 rats were induced diabetic with streptozotocin (STZ) dose of 50 mg/kg body weight of rats which divided into 3 groups that has been stained with hematoxillin-eosin and cytokeratin 19. They are P1 treated with thymoquinone (Tq), P2 treated with metformin, and K without treatment. Each group consist of 9 rats were divided into 3 subgroups based on day of observation. They are 3rd, 7th and 10th day post-extraction. Re-epithelialization was observed at the margin of the tooth socket that has been stained with hematoxillin-eosin and cytokeratin 19Results: showed there was an improvement of re epithelialization percentage in the Tq treatment group compared with P2 and K groups.Conclusion: Thymoquinone extract may decrease blood glucose level and increasing re-epithelialization in margin of the tooth socket after extraction in diabetic rats.
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How to Cite
Syafriadi, M., Yusuf, P. R., Pratama, S. M., Ummah, D. Z., & Amalia, K. (2018). The correlation of consuming thymoquinone extract of nigella sativa to tooth socket re-epithelization on diabetic-induced rats. Journal of Dentomaxillofacial Science, 3(2), 79–83. https://doi.org/10.15562/jdmfs.v3i2.742
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improves gastrointestinal tolerability. Br J Diabetes Vasc
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metformin: metformin induced hepatoxicity. Turk J Med
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healing revised: a novel re-epithelialization mechanism
revealed by in vitro and in silico models. J Biophys
Biochem Cytol 2013;203: 691-709.
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on hepatic key enzymes in streptozotocinnicotinamide
induced diabetic rats. Life Sciences 2009;85:
830-834.
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in wound epithelization. WOUND CARE 2014;3: 482-491.
19. Abdelmeguid NE, Fakhoury R, Kamal SM, et al. Original
article: effects of nigella sativa and thymoquinone on
biochemical and subcellular changes in pancreatic BCells
of streptozotocin induced diabetic rats. J Diabetes
2010;2: 256-266.
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pyruvate carboxykinase gene experession by metformin in
cultured hepatocytes. Chin Med J 2002;115: 1843-1848.
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of metformin. Clin Pharmacokinet 2011;50: 81-98.
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by reactive oxygen species: fifteen years later. Biochem
Pharmacol 2006;72: 1493-1505.
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activities of some Indonesian Herbs: In Vitro Study. The
12th ASEAN food Conference. 2011
2. Guyton AC, Hall JE. Buku Ajar Fisiologi Kedokteran. 11th
ed. Jakarta: EGC; 2006.
3. Kementerian Kesehatan. Riset Kesehatan Dasar. 2013.
4. Sudoyo AW, Setiyohadi B, Alwi I, et al. Buku Ajar Ilmu
Penyakit Dalam. Jakarta: Internal Publishing; 2009.
5. Al-Farabi MJ. Antibodi terhadap advanced glycation end
product, cara mutakhir pencegahan komplikasi diabetes
mellitus. CDK 2013;40: 807-814.
6. Collison KS, Parhar RS, Saleh SS, et al. RAGE- ediated neutrophil
dysfunction is evoked by advanced glycation end
products (AGEs). J Leukoc Biol 2002;71: 433-444.
7. Abiko Y, Selimovic D. The mechanism of protracted
wound healing on oral mucose in diabetes. Review Bosn J
Basic Med Sci 2010;10: 186-191.
8. Radoi V, Lixandru D, Mohora M, et al. Advanced glycation
end products in diabetes mellitus: mechanism of action and
focused treatment. Proc Rom Acad Series B 2012;1: 9-19.
9. Huang S, Dang H, Huynh W, et al. The healing of dental
extraction sockets in patients with type 2 diabetes on
oral hypoglycaemics: a prospective cohort. Aust Dent J
2013;58: 89-93.
10. Torres-Lagares D, Srrera-Figallo MA, RomeroRu’iz MM,
et al. Update on dry socket: a review of the literature. Med
Oral Patol Oral Cir Bucal 2005;10: 77-85.
11. Vernillo AT. Dental consideration for the treatment of
patients with diabetes mellitus. Am Dent Asscoc 2003;134:
24-33.
12. Davidson J, Howlett H. New prolonged-release metformin
improves gastrointestinal tolerability. Br J Diabetes Vasc
Dis 2004;4: 273-277.
13. Aksay E, Yanturali S, Bayram B, et al. A rare side effect of
metformin: metformin induced hepatoxicity. Turk J Med
Sci 2007;37: 173-175.
14. Kaleem M, Kirmani D, Asif M, et al. Biochemical effect
of nigella sativa l seeds in diabetic rats. Indian J Exp Biol
2006;44: 745-748.
15. Paarakh PM. Nigella sativa linn. a comprehensive review.
Indian J Nat Prod Resour 2010;1: 409-429.
16. Safferling K, Sutterlin T, Westpal K, et al. Wound
healing revised: a novel re-epithelialization mechanism
revealed by in vitro and in silico models. J Biophys
Biochem Cytol 2013;203: 691-709.
17. Pari, Sankaranarayanan C. Beneficial effects of thymoquinone
on hepatic key enzymes in streptozotocinnicotinamide
induced diabetic rats. Life Sciences 2009;85:
830-834.
18. Ramirez H, Patel SB, Pastar I. The role of TGF-β signaling
in wound epithelization. WOUND CARE 2014;3: 482-491.
19. Abdelmeguid NE, Fakhoury R, Kamal SM, et al. Original
article: effects of nigella sativa and thymoquinone on
biochemical and subcellular changes in pancreatic BCells
of streptozotocin induced diabetic rats. J Diabetes
2010;2: 256-266.
20. Yuan L, Ziegler R, Hamann A. Inhibition of phosphoenol
pyruvate carboxykinase gene experession by metformin in
cultured hepatocytes. Chin Med J 2002;115: 1843-1848.
21. Graham GG, Punt J, Arora M, et al. Clinical pharmacokinetics
of metformin. Clin Pharmacokinet 2011;50: 81-98.
22. Gloire G, Legrand-Poels S, Piette J. NF-kB activation
by reactive oxygen species: fifteen years later. Biochem
Pharmacol 2006;72: 1493-1505.
23. Koivisto L, HÓ“kkinen L, Larjava H. Reepithelization of
wound healing: cell biology and clinical management 1st ed.
John Wiley & Sons Inc. 2012.