Original Article

Effects of vasoconstrictor on arterial blood pressure during minor oral surgical procedures

Abubakar M. Kaura, Babatunde O. Bamgbose , S.A.B Ogunwande, Amole I.O, Junichi Asaumi, Thomas Owobu

Abubakar M. Kaura
Oral & Maxillofacial Surgery Department, Faculty of Dentistry, Bayero University Kano &Aminu Kano Teaching Hospital Kano

Babatunde O. Bamgbose
Department of Oral and Maxillofacial Radiology and Surgery, Lagos University Teaching Hospital, Lagos, Nigeria. Email: drtundebamgbose@yahoo.com

S.A.B Ogunwande
Department of Surgery, Bowen University, Nigeria

Amole I.O
Department, Oral & Maxillofacial Surgery, Aminu Kano Teaching Hospital & Bayero University Kano

Junichi Asaumi
Oral and Maxillofacial Radiology, Okayama University, Okayama, Japan

Thomas Owobu
Department of Dental Surgery, FMC Nguru, Yobe State, Nigeria
Online First: December 01, 2018 | Cite this Article
Kaura, A., Bamgbose, B., Ogunwande, S., I.O, A., Asaumi, J., Owobu, T. 2018. Effects of vasoconstrictor on arterial blood pressure during minor oral surgical procedures. Journal of Dentomaxillofacial Science 3(3): 136-143. DOI:10.15562/jdmfs.v3i3.768


Objective: A majority of minor oral surgical procedures require the use of local anaesthetics containing vasoconstrictors as part of the composition. These vasoconstrictors cause some hemodynamic changes either by direct action on the cardiac muscle or by stimulation of the autonomic innervations of the heart. Depending on the concentration of the vasoconstrictor, an increased heart rate, increased force of cardiac contraction, and ultimately increased blood pressure may ensue. The aim of this study was to assess the effect of vasoconstrictors contained in local anaesthetics on arterial blood pressure during minor oral surgical procedures.

Material and Methods: This was a one-year prospective, randomized, comparative study involving the assessment of blood pressure and pulse rate by using an electronic digital blood pressure monitoring device amongst consenting patients who were referred for tooth extraction. The potential research participants were randomly allocated into either the study or the control group. The study group was treated using 2% lignocaine with 1:80,000 epinephrine, while the control was treated using 2% plain lignocaine (without epinephrine). Normal or controlled-hypertensive patients between the ages of 18 to 55 years were enrolled into the study.

Results: A total of 100 subjects with a mean age of 34.66±10.3 years participated in the study. There was no statistically significant difference in blood pressure and pulse rate between the patients in both the study group and control group.

Conclusion: Optimal use of adrenaline-containing local anaesthetic does not cause a statistically significant increase in blood pressure or pulse rate.

References

Clayton L, Thomas. Taber’s cyclopedic medical dictionary. 18th ed. Philadelphia: F.A Davis; 1997. p. 1868.

Gregory PH. Protocol for the management of oral surgery patients on warfarin utilizing a Point-of-Care In-Office international normalized ratio monitoring device. Open journal of stomatology 2013;3: 255-267.

Brown G. The influence of adrenaline, noradrenaline vasoconstrictors on the efficacy of lidocaine. J Oral Ther Pharmacol 1968;4: 398-405.

Gungormus M, Buyukkurt MC. The evaluation of changes in blood pressure and pulse rate of hypertensive patients during Tooth Extraction. Acta Med Austriaca 2003;30: 127-129.

Haas DA. An update on local anaesthetics in dentistry. J Can Assoc 2002;68: 546-551.

Sotunmbi PT, Arotiba JT. A manual of anaesthesia for dental and maxillofacial surgery. 1st ed. Nigeria: Ambod Publishers; 2005. p. 72-102.

Brand HS. Cardiovascular responses in patient and dentist during dental treatment. Int Dent J 1999;49: 60-66.

Maria TFC, Ana Cristina PL, Fabio SB, et al. Effect of local anesthetics with and without vasconstrictor agent in patients with ventricular arrhythmias. Arq Bras Cardiol 2008;91: 128-133.

Yagiela JA, Duffin SR, Hunt IM. Drug interactions and vasoconstritors used local solutions. Oral Surg Oral Med Oral Pathol 1985;59: 565-571.

Perusse R, Goulet JP, Turcotte JY. Contraindications to vasoconstrictor in dentistry: Part I. Cardiovascular diseases. Oral Surg Oral Med Oral Pathol 1992;74: 679-686.

Adediran OS, Okpara IC, Adeniyi OS, et al. Hypertension prevalence in an urban and rural area of Nigeria. J Med Med Sci 2013;4: 149-154.

Akpata ES. Oral health in Nigeria. Int Dent J 2004;54: 361-366.

Niwa H, Sugimura M, Satoh Y, Tanimoto A. Cardiovascular res¬ponse to epinephrine-containing local anesthesia in patients with cardiovascular disease. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;92: 610-616.

Cioffi GA, Chernow B, Glahn RP, Terezhalmy GT, Lake CR. The hemodynamic and plasma catecholamine responses to routine res¬torative dental care. J Am Dent Assoc 1985;111: 67-70.

Muzkeya BC, Glick M. The hypertensive dental patient. J Am Dent Assoc 1997;128: 1109-1120.

Agency for Health Research and Quality (AHQR); Cardiovascular Effects of epinephrine in hypertensive dental patients; Number 48 AHQR Publication 02 –E005, March 2002.

Ogunlewe MO, James O, Ajuluchukwu JN, et al. Evaluation of hemodynamic changes in hypertensive patients during tooth extraction under local anesthesia. West Indian Med J 2011;60: 91-95.

Mohammad AG, Javad Y, Arezo GZ, et al. Comparison of heart rate and blood pressure after administration of anesthetic agent with and without vasoconstrictor. Int J Curr Res Acad Rev 2014;2: 153-158.

Marcelo C, Bortoluzzi, Rafael M, et al. Glucose levels and hemodynamic changes in patients submitted to routine dental treatment with and without local anesthesia. Clinics 2010;65: 975-978.

Chaudary S, Iqbal HA, Izhar F et al. Effect on blood pressure and pulse rate after administration of an epinephrine containing dental local anesthetic in hypertensive patients. J Pak Med Assoc 2011;61: 1088-1099.

de-Morais HH, de-Santana ST, da-Costa FA, et al. Hemodynamic changes comparing 2% lidocaine and 4% articaine with epinephrine 1: 100,000 in lower third molar surgery. J Craniofac Surg 2012;23: 1204-1211.

Akinmoladun VN, Okoje OM, Akinosun AO, et al. Evaluation of haemodynamic and metabolic effects of local anaesthetic agent in routine dental extractions. J Maxillofac Oral Surg 2013;12: 424-428.

Nedal AM, Fatimah A, Kawther A, et al. hemodynamic changes following injection of local anesthetics with different concentrations of epinephrine during simple tooth extraction: a prospective randomized clinical trial. J Clin Exp Dent 2015;7: e471-e476.


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