A Systematic Review

Role of secretome mesenchymal stem cells as immunomodulator in periodontal diseases

Desi S. Sari, Ernie Maduratna, Candra Bumi, I-Ketut Sudiana , Fedik A. Rantam

Desi S. Sari
Department of Periodontics, Faculty of Dentistry, Universitas Jember, Jember, Indonesia

Ernie Maduratna
Department of Periodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia

Candra Bumi
Department of Epidemiology and Biostatistics Population, Universitas Jember, Jember, Indonesia

I-Ketut Sudiana
Department of Mikroskop Elektron, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. Email: ik.sudiana@yahoo.com

Fedik A. Rantam
Department of Regenerative Medicine and Stem Cell Center, Universitas Airlangga/Dr Soetomo General Hospital, Surabaya, Indonesia Department of Stem Cells Research and Development Center, Universitas Airlangga, Surabaya, Indonesia
Online First: December 01, 2021 | Cite this Article
Sari, D., Maduratna, E., Bumi, C., Sudiana, I., Rantam, F. 2021. Role of secretome mesenchymal stem cells as immunomodulator in periodontal diseases. Journal of Dentomaxillofacial Science 6(3): 139-146. DOI:10.15562/jdmfs.v6i3.989


Objective: The purpose of this review literature is to look at the mechanism of mesenchymal stem cell secretome in the regeneration of periodontal tissue.

Methods: This literature review was collected from several journals and research that has been done, where the application of Mesenchymal stem cells (MSCs) promises a favourable result for cell-based therapy in inflammatory diseases, immune system disorders, regeneration, and tissue repair.

Results: MSCs possess a potent immunomodulatory function, paracrine effects, and the ability to differentiate into different cells. Not only mesenchymal stem cells can replace damaged tissue or cells but also secrete secretome namely bioactive ingredients such as cytokines, chemokines, growth factors, pro-inflammatory, and anti-inflammatory which play an essential role in regulating the host immune system. Periodontal disease is an inflammatory disease that occurs in the teeth supporting structures. Lately, many therapies for periodontal disease utilized MSCs from gingival tissue and periodontal ligaments. Secretome activates endogenous MSCs to improve the immune system in periodontal disease that might create a better microenvironment of periodontal tissue.

Conclusion: The secretome of MSCs has attracted a lot of attention and has the potential to repair and regenerate tissues including periodontal tissue

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