Original Article

The effectiveness methanol extract clausena excavate on number of fibroblast and density of collagen fibers after tooth extraction

Efa Ismardianita , Widyawati Widyawati, Dewi Elianora, Wenny Rosalina, Lusi Nofrike, Vivi Y. Khairani

Efa Ismardianita
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Baiturrahmah, Padang, Indonesia. Email: efa_ismardianita@yahoo.co.id

Widyawati Widyawati
Department of Conservative, Faculty of Dentistry, University of Baiturrahmah, Padang, Indonesia

Dewi Elianora
Department of Pediatric Dentistry, Faculty of Dentistry, University of Baiturrahmah, Padang, Indonesia

Wenny Rosalina
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Baiturrahmah, Padang, Indonesia

Lusi Nofrike
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Baiturrahmah, Padang, Indonesia

Vivi Y. Khairani
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Baiturrahmah, Padang, Indonesia
Online First: December 01, 2019 | Cite this Article
Ismardianita, E., Widyawati, W., Elianora, D., Rosalina, W., Nofrike, L., Khairani, V. 2019. The effectiveness methanol extract clausena excavate on number of fibroblast and density of collagen fibers after tooth extraction. Journal of Dentomaxillofacial Science 4(3): 170-175. DOI:10.15562/jdmfs.v4i3.996


Objective: This study is made to identify the effect of extracts in Clausena excavata 50% on the number of fibroblasts and the density of collagen fiber in recovery after tooth extraction.

Material and Methods: This is a true experimental designed with post-test only control group design, using 24 rats were divided into two groups, each group of three rats. Lower incisor tooth extraction performed lower left, into the tooth socket CMC applied to the control group and 0.5% extract treatment group Clausena excavata 50%. The number density of fibroblasts and collagen fibers were observed on days 3, 7, 14 and 21 with Haematoxylin Eosin staining and Mallory. The differences in density of collagen fibers observation group with Kruskal-Wallis test.

Results: There are significant differences in a number of fibroblasts and density of collagen fibers between a control group and socket treatment group (p <0.05).

Conclusion: The extract Clausena excavata 50% can fasten the wound recovery by increasing the number of fibroblasts and collagen fibers.

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