Original Article

Study on swelling behaviour of HANP/PVA composites with adding PLGA for alveolar ridge preservation

Feni Istikharoh , Hidayat Sujuti, Edi Mustamsir, Astika Swastirani

Feni Istikharoh
Department of Dental Materials, Faculty of Dentistry, Universitas Brawijaya, Malang, Indonesia Department of Biomedical Science, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia. Email: feni.istikharoh@ub.ac.id

Hidayat Sujuti
Department of Biochemistry, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia

Edi Mustamsir
Department of Orthopaedic, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia

Astika Swastirani
Department of Oral Medicine, Faculty of Dentistry, Universitas Brawijaya, Malang, Indonesia
Online First: December 01, 2021 | Cite this Article
Istikharoh, F., Sujuti, H., Mustamsir, E., Swastirani, A. 2021. Study on swelling behaviour of HANP/PVA composites with adding PLGA for alveolar ridge preservation. Journal of Dentomaxillofacial Science 6(3): 197-199. DOI:10.15562/jdmfs.v6i3.998


Objective: The aim of this study was to compare the swelling behaviour of Hand Polyvinyl Acetate/Polyvinyl alcohol (HANP/PVA) and HANP/PVA/Poly Lactic-co-Glycolic Acid (PLGA) composites.

Material and Methods: This study was divided into 2 groups, HANP/PVA and HANP/PLGA/PVA composites which prepared by freeze drying methods. HANP 20% (w/w) was combined with PLGA 20% (w/w) and dissolved in PVA solution at 50oC. Swelling behaviour was obtained by measured initial weight (Wi) and the weight of composites after immersing in PBS pH 7.4; 37oC for 7 days (swollen weight (Ws)). Statistical analysis based on Independent T-test (p<0.05).

Results: The Wi of HANP/PVA and HANP/PLGA/PVA composites are 467±4.73 and 292±9.52. The Ws of HANP/PVA and HANP/PLGA/PVA composites are 897±26.61 and 860±32.36. Furthermore, the water retention of HANP/PVA composite is 92.07% (p<0.05) and HANP/PLGA/PVA composite is 194.52% (p<0.05).

Conclusion: The addition of PLGA enhance swelling behaviour of HANP/PVA composites. The strong interaction between HANP and PVA decrease the swelling re. HANP is inert in nature, but the combination of HANP/PLGA/PVA can be a good substitute for alveolar preservation.

 

References

Baniasadi B, Evrard L. Alveolar ridge preservation after tooth extraction with dfdba and platelet concentrates: A radiographic retrospective study. Dent J 2017;11: 99-108.

Levengood SL, Zhang M. Chitosan-based scaffolds for bone tissue engineering. J Mater Chem B Mater Biol Med 2014;2: 3161-3184.

Sheikh Z, Najeeb S, Khurshid Z, et al. Biodegradable materials for bone repair and tissue engineering application. Mater 2015;8: 5744-5794.

Hansson S, Halldin A. Alveolar ridge resorption after tooth extraction: A consequence of fundamental principle of bone physiology. J Dent Biomech 2012;3: 1-6.

Hong CE, Lee JY, Joo JY. Prediction the alveolar bone level after the extraction of maxillary anterior teeth with severe periodontitis. J Periodon Imp Sci 2015;45: 216-222.

Loh QH, Choong C. Three-Dimensional scaffold scaffolds for tissue engineering applications: Role of porosity and pore size. Tiss Eng Part B 2013;19: 485-502.

Karthik V, Pabi SK, Chowdhury SKR. Development of hydroxyapatite/polyvinyl alcohol bionanocomposite for prothesis implants. Mater Sci Eng 2018;314: 1-6.

Kumar P, Dehiya BS, Sindhu A. Ibuprofen-Loaded CTS/nHA/nBG Scaffolds for the applications of hard tissue engineering. Iran Biomed J 2019;23: 190-199.

Dewi AH, Ana ID. The use of hydroxyapatite bone substitute grafting for alveolar ridge preservation, sinus augmentation, and periodontal bone defect: A systematic review. Heliyon 2018;4: 1-10.

Kumar P. Nano-TiO2 doped chitosan scaffold for the bone tissue engineering applications. Int J Biomater 2018;7: 1-8.

Maji K, Dasgupta S, Pramanik K, et al. Preparation and evaluation of gelatin-chitosan-nanobioglass 3d porous scaffold for bone tissue engineering. Int J Biomater 2016;2016: 14.

Jana S, Florczyk SJ, Leung M, et al. High-strength pristine porous chitosan scaffolds for tissue engineering. J Mater Chem 2012;22: 6291.

Kapoor DN, Bhatia A, Kaur R, et al. PLGA: A unique polymer for drug delivery. Ther Deliv 2015;6: 41-58.

Balgova Z, Palou M, Wasserbauer J, et al. Synthesis of poly (vinyl alcohol) - hydroxyapatite composites and characterization of their bioactivity. Cent Eur J Chem 2013;9: 1401-1411.

Ashraf AA, Zebarjad SM, Hadianfard MJ. The cross-linked polyvinyl alcohol/hydroxyapatite nanocomposite foam. J Mater Res Technol 2019;8: 3149-3157.


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