Study on swelling behaviour of HANP/PVA composites with adding PLGA for alveolar ridge preservation
Abstract
Objective: The aim of this study was to compare the swelling behaviour of Hand Polyvinyl Acetate/Polyvinyl alcohol (HANP/PVA) and HANP/PVA/Poly Lactic-co-Glycolic Acid (PLGA) composites.Material and Methods: This study was divided into 2 groups, HANP/PVA and HANP/PLGA/PVA composites which prepared by freeze drying methods. HANP 20% (w/w) was combined with PLGA 20% (w/w) and dissolved in PVA solution at 50oC. Swelling behaviour was obtained by measured initial weight (Wi) and the weight of composites after immersing in PBS pH 7.4; 37oC for 7 days (swollen weight (Ws)). Statistical analysis based on Independent T-test (p<0.05).Results: The Wi of HANP/PVA and HANP/PLGA/PVA composites are 467±4.73 and 292±9.52. The Ws of HANP/PVA and HANP/PLGA/PVA composites are 897±26.61 and 860±32.36. Furthermore, the water retention of HANP/PVA composite is 92.07% (p<0.05) and HANP/PLGA/PVA composite is 194.52% (p<0.05).Conclusion: The addition of PLGA enhance swelling behaviour of HANP/PVA composites. The strong interaction between HANP and PVA decrease the swelling re. HANP is inert in nature, but the combination of HANP/PLGA/PVA can be a good substitute for alveolar preservation.
Section
References
- Baniasadi B, Evrard L. Alveolar ridge preservation after tooth extraction with dfdba and platelet concentrates: A radiographic retrospective study. Dent J 2017;11: 99-108.
- Levengood SL, Zhang M. Chitosan-based scaffolds for bone tissue engineering. J Mater Chem B Mater Biol Med 2014;2: 3161-3184.
- Sheikh Z, Najeeb S, Khurshid Z, et al. Biodegradable materials for bone repair and tissue engineering application. Mater 2015;8: 5744-5794.
- Hansson S, Halldin A. Alveolar ridge resorption after tooth extraction: A consequence of fundamental principle of bone physiology. J Dent Biomech 2012;3: 1-6.
- Hong CE, Lee JY, Joo JY. Prediction the alveolar bone level after the extraction of maxillary anterior teeth with severe periodontitis. J Periodon Imp Sci 2015;45: 216-222.
- Loh QH, Choong C. Three-Dimensional scaffold scaffolds for tissue engineering applications: Role of porosity and pore size. Tiss Eng Part B 2013;19: 485-502.
- Karthik V, Pabi SK, Chowdhury SKR. Development of hydroxyapatite/polyvinyl alcohol bionanocomposite for prothesis implants. Mater Sci Eng 2018;314: 1-6.
- Kumar P, Dehiya BS, Sindhu A. Ibuprofen-Loaded CTS/nHA/nBG Scaffolds for the applications of hard tissue engineering. Iran Biomed J 2019;23: 190-199.
- Dewi AH, Ana ID. The use of hydroxyapatite bone substitute grafting for alveolar ridge preservation, sinus augmentation, and periodontal bone defect: A systematic review. Heliyon 2018;4: 1-10.
- Kumar P. Nano-TiO2 doped chitosan scaffold for the bone tissue engineering applications. Int J Biomater 2018;7: 1-8.
- Maji K, Dasgupta S, Pramanik K, et al. Preparation and evaluation of gelatin-chitosan-nanobioglass 3d porous scaffold for bone tissue engineering. Int J Biomater 2016;2016: 14.
- Jana S, Florczyk SJ, Leung M, et al. High-strength pristine porous chitosan scaffolds for tissue engineering. J Mater Chem 2012;22: 6291.
- Kapoor DN, Bhatia A, Kaur R, et al. PLGA: A unique polymer for drug delivery. Ther Deliv 2015;6: 41-58.
- Balgova Z, Palou M, Wasserbauer J, et al. Synthesis of poly (vinyl alcohol) - hydroxyapatite composites and characterization of their bioactivity. Cent Eur J Chem 2013;9: 1401-1411.
- Ashraf AA, Zebarjad SM, Hadianfard MJ. The cross-linked polyvinyl alcohol/hydroxyapatite nanocomposite foam. J Mater Res Technol 2019;8: 3149-3157.
How to Cite
Istikharoh, F., Sujuti, H., Mustamsir, E., & Swastirani, A. (2021). Study on swelling behaviour of HANP/PVA composites with adding PLGA for alveolar ridge preservation. Journal of Dentomaxillofacial Science, 6(3), 197–199. https://doi.org/10.15562/jdmfs.v6i3.998
